Nonsteroidal anti-inflammatory drugs work by blocking an enzyme called cyclo-oxygenase, which exists in the body in two forms, COX-1 and COX-2.

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Both Celebrex and Vioxx belong to a class of drugs known as COX-2 inhibitors, as does Bextra.

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Celebrex (Searle and Pfizer Inc) is indicated for the relief of the pain and inflammation of osteoarthritis and adult rheumatoid arthritis.

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